Setup initial file structure
This commit is contained in:
174
Modules/ado/plus/m/metaninf.hlp
Normal file
174
Modules/ado/plus/m/metaninf.hlp
Normal file
@ -0,0 +1,174 @@
|
||||
.-
|
||||
help for ^metaninf^ version 1.0.2
|
||||
.-
|
||||
|
||||
Influence of a single study in meta-analysis estimation
|
||||
-------------------------------------------------------
|
||||
|
||||
^metaninf^ varlist [^if^ exp] [^in^ range] [, ^fixed fixedi random randomi^
|
||||
^rr or rd peto cornfield hedges cohen glass nosta^ndard
|
||||
^label(^label_vars^) il^evel^(^#^) ol^evel^(^#^) notable nograph^
|
||||
^sav^e^(^varname [^, replace^]^)^ ]
|
||||
|
||||
|
||||
Description
|
||||
-----------
|
||||
|
||||
^metaninf^ investigates the influence of each individual study on the overall
|
||||
meta-analysis summary estimate. The command presents a table and a graph of
|
||||
the results of an influence analysis in which the meta-analysis is reestimated
|
||||
omitting each study in turn.
|
||||
|
||||
The table numerically provides the results, with the rows of the table being
|
||||
the meta-analysis of all studies except the "omitted" study named in that row,
|
||||
and the usual, full meta-analysis (omitting none of the studies) being given
|
||||
as the "combined" results at the bottom of the table.
|
||||
|
||||
The graph visually provides the same results in a plot, naming the omitted
|
||||
study on the left margin and presenting the resulting "omitted" meta-analytic
|
||||
summary statistics as a horizontal confidence interval. The full, "combined"
|
||||
results are shown as the solid vertical lines.
|
||||
|
||||
No formal test of influence is given; rather, the program provides and displays
|
||||
results to which some general guidelines can be applied to assess influence.
|
||||
One such guideline is that an individual study is suspected of excessive
|
||||
influence if the point estimate of its "omitted" analysis lies outside the
|
||||
confidence interval of the "combined" analysis. Another quideline is that a
|
||||
study is excessively influential if its "omitted" meta-analytic estimate
|
||||
differs in significance relative to the "combined" analysis. Neither of these
|
||||
quidelines provides definitive proof that such a study should, or should not,
|
||||
be removed from the analysis; they merely provide a suggestion that some
|
||||
attention be paid to potential reasons for its influence.
|
||||
|
||||
^metaninf^ uses program ^metan^ as its meta-analysis engine and its options are
|
||||
a direct subset of ^metan^'s. It is expected that users will merely edit a ^metan^
|
||||
command line by adding the "inf" suffix to the program name to run ^metaninf^.
|
||||
|
||||
Like ^metan^, ^metaninf^ requires either four or six variables to be declared.
|
||||
When four variables are specified, analysis of binary data is performed.
|
||||
When six variables are specified, the data are assumed continuous.
|
||||
|
||||
Binary data is presented as the 4 cell counts (a b c d) of a 2x2 table where
|
||||
a and b are the number of event & no-event subjects in the intervention group
|
||||
and c and d are similar numbers for the control group.
|
||||
|
||||
. ^metaninf a b c d^
|
||||
|
||||
Continuous data is presented as 6 values: the n, mean and sd for the treatment
|
||||
(or intervention) group followed by similar values for the control group.
|
||||
|
||||
. ^metaninf nt mt sdt nc mc sdc^
|
||||
|
||||
|
||||
Options
|
||||
-------
|
||||
|
||||
Scaling and pooling options
|
||||
---------------------------
|
||||
|
||||
Options for binary data
|
||||
|
||||
^rr^ pools risk ratios (the default).
|
||||
|
||||
^or^ pools odds ratios.
|
||||
|
||||
^rd^ pools risk differences.
|
||||
|
||||
^fixed^ specifies a fixed effect model using the method of Mantel & Haenszel
|
||||
(the default).
|
||||
|
||||
^fixedi^ specifies a fixed effect model using the inverse variance method.
|
||||
|
||||
^peto^ specifies that Peto's assumption free method is used to pool odds
|
||||
ratios.
|
||||
|
||||
^random^ specifies a random effects model using the method of DerSimonian &
|
||||
Laird, with the estimate of heterogeneity being taken from the
|
||||
Mantel-Haenszel model.
|
||||
|
||||
^randomi^ specifies a random effects model using the method of DerSimonian &
|
||||
Laird, with the estimate of heterogeneity being taken from the inverse
|
||||
variance fixed effect model.
|
||||
|
||||
^cornfield^ computes confidence intervals for odds ratios by the method of
|
||||
Cornfield, rather than the (default) Woolf method.
|
||||
|
||||
|
||||
Options for continuous data
|
||||
|
||||
^cohen^ pools standardized mean differences by the method of Cohen
|
||||
(the default).
|
||||
|
||||
^hedges^ pools standardized mean differences by the method of Hedges.
|
||||
|
||||
^glass^ pools standardized mean differences by the method of Glass.
|
||||
|
||||
^nostandard^ pools unstandardized mean differences.
|
||||
|
||||
^fixed^ specifies a fixed effect model using the inverse variance method
|
||||
(the default).
|
||||
|
||||
^random^ specifies a random effects model using the DerSimonian & Laird
|
||||
method.
|
||||
|
||||
|
||||
General output options
|
||||
----------------------
|
||||
|
||||
^label(^[^namevar^=namevar] [^, yearvar^=yearvar]^)^
|
||||
labels the data by its name, year or both. However, neither option
|
||||
is required. For the table display the overall length of the label is
|
||||
restricted to 16 characters.
|
||||
|
||||
^ilevel()^ specifies the significance level (eg 90,95,99) for the
|
||||
individual trial confidence intervals.
|
||||
|
||||
^olevel()^ specifies the significance level (eg 90,95,99) for the
|
||||
overall (pooled) confidence intervals.
|
||||
|
||||
^ilevel^ and ^olevel^ need not be the same, and by default are equal
|
||||
to the significance level specified using the ^set level^ command.
|
||||
|
||||
^notable^ prevents display of the table of results.
|
||||
|
||||
^nograph^ prevents display of the graph.
|
||||
|
||||
^save(^varname [^, replace^]^)^ saves the jackknifed estimates.
|
||||
|
||||
|
||||
Note
|
||||
----
|
||||
|
||||
To run ^metaninf^, the ^metan^ command [STB-44: sbe24] must be installed.
|
||||
|
||||
|
||||
Acknowledgements
|
||||
----------------
|
||||
|
||||
^metaninf^ is a direct rip-off of ^metainf^ (by Aurelio Tobias; see STB-47: sbe26;
|
||||
STB-56: sbe26.1). It blatently uses ^metan^ (by Michael J Bradburn, Jonathan J
|
||||
Deeks and Douglas G Altman; see STB-44: sbe24) as its meta-analysis calculation
|
||||
engine and ^mhplot^, a slight variation of ^hplot^ (by Nicolas Cox), as its
|
||||
graphic engine. The current author is indebted to the above authors for all
|
||||
their hard work, thus allowing this program to be written with no apparent
|
||||
personal intellectual input. Thanks guys!
|
||||
|
||||
|
||||
Examples
|
||||
--------
|
||||
|
||||
. ^metaninf a b c d, fixedi or label(namevar=studyid, yearvar=year)^
|
||||
. ^metaninf nt mt sdt nc mc sdc, cohen notable^
|
||||
|
||||
|
||||
Author
|
||||
------
|
||||
|
||||
Thomas J Steichen, steichen@triad.rr.com
|
||||
|
||||
|
||||
Also see
|
||||
--------
|
||||
|
||||
On-line: help for @metan@, and if installed: @metainf@, @meta@, @metareg@, @metacum@,
|
||||
@metabias@, @metatrim@, @metap@, @galbr@, @funnel@, @labbe@, and @hplot@.
|
||||
Reference in New Issue
Block a user